Gradient Biotech

Overview

Neurology workflows connect brain connectivity, functional imaging, and electrophysiology data in a single study workspace. Each use case below maps a common research question to platform capabilities, data requirements, and a suggested analysis path.

Use case index

Use caseResearch questionKey capabilities
Connectome analysisWhat is the topology of this brain network?Graph metrics, heatmap and 3D visualization, AI interpretation
Resting-state fMRIHow does functional connectivity differ across a cohort?BIDS validation, functional connectivity, dynamic FC, atlas parcellation
EEG connectivityWhat spectral and connectivity features characterize this recording?EEG preprocessing, band power, PLV/coherence, microstates, graph metrics
Cohort comparisonWhich edges or graph metrics differ between groups?Group assignment, batch graph metrics, NBS, cohort metric comparison
Predictive biomarkersCan connectivity edges predict a group or score out-of-sample?NBS-Predict cross-validated classification and regression, permutation testing, edge-stability maps
Intracranial EEG (iEEG/ECoG)Which intracranial contacts show event-related high-gamma activation?Shaft-aware bipolar referencing, high-gamma band power, peri-event high-gamma mapping

Who these use cases serve

AudienceTypical goals
Neuroscience researchersfMRI/EEG connectivity analysis, graph metrics, reproducible pipelines
Psychiatry and neurology research groupsGroup-level connectivity differences, biomarker discovery
Cognitive neuroscience labsResting-state and task-based fMRI without MATLAB/SPM setup
Neurotech and digital health teamsEEG feature extraction, microstate analysis, biomarker pipelines
Pharma and clinical trial teamsConnectivity endpoints, treatment-response analysis, reproducible imaging workflows
Epilepsy, neurosurgery, and BCI research teamsIntracranial (iEEG/ECoG) bipolar referencing, high-gamma functional mapping

Common data requirements

Most use cases start with a neurology study containing:

  • Datasets — connectivity matrices, EEG recordings, or fMRI NIfTI/BIDS archives
  • Subjects (optional) — participant metadata with diagnosis, group label, and cognitive scores
  • Group labels — assigned per dataset for cohort comparison and NBS

Choosing a starting point

If your primary data is…Start with…
Precomputed ROI connectivity matrixConnectome analysis
Resting-state fMRI NIfTI or BIDSResting-state fMRI
EEG or MEG recordingEEG connectivity
Multiple subjects with group labelsCohort comparison
Subjects with an outcome to predict (group or score)Predictive biomarkers
Intracranial depth/grid electrode recordingIntracranial EEG (iEEG/ECoG)

What these use cases are not

These workflows support exploratory neuroscience research. They are not clinical diagnostic or neurological assessment tools. All AI interpretation outputs include research disclaimers and cite computed metrics only.

Next steps