Tumor microenvironment, immune response, mutations, and outcomes
The Oncology area is a research workspace for tumor cohorts and translational oncology studies. Organize samples, clinical endpoints, mutation and repertoire data; run tumor microenvironment, immune phenotype, communication, mutation, and survival workflows; and interpret computed results with provenance.
Use cases
Guided workflows map common questions to data requirements, analysis steps, and documentation — pick the scenario closest to your study.
Research question: Why do some patients respond to anti-PD-1 / anti-PD-L1 therapy while others do not? Which immune features — infiltration, exclusion, exhaustion, repertoire diversity — best separate response groups?
Stratify checkpoint inhibitor cohorts by immune phenotype, exhaustion state, and signaling patterns to understand responder vs. non-responder biology.
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Research question: Which mutational features — TMB, specific driver genes, copy number alterations, or mutational signatures — associate with overall survival, progression-free survival, or treatment response in my cohort?
Connect somatic mutation landscapes to clinical endpoints — TMB, driver alterations, mutational signatures, and oncoprint summaries stratified by survival or response.
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Research question: What cell types populate the tumor microenvironment, and which ligand-receptor signaling networks regulate immune activation, suppression, or exclusion?
Profile tumor microenvironment composition and identify dominant cell-cell communication axes across immune, stromal, and malignant populations.
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Research question: How do TME composition, immune phenotype, mutational features, and signaling patterns combine to explain treatment response and clinical outcomes across my cohort?
Connect single-cell, bulk, mutation, repertoire, and clinical data in one oncology study — from molecular profiling through survival analysis and analysis.
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Capabilities
Everything available in the Oncology workspace today — pipelines, explorers, exports, and provenance.